AMP-activated protein kinase (AMPK) is a central metabolic regulator that promotes cancer growth and survival under hypoxia and plays a role in the maintenance of cancer stem cells. A major challenge to interrogating the potential of targeting AMPK in cancer is the lack of potent and selective small molecule inhibitors. Compound C has been widely used as an AMPK inhibitor, but it lacks potency and has a poor selectivity profile. The multi-kinase inhibitor, sunitinib, has demonstrated potent nanomolar inhibition of AMPK activity and has scope for modification. Here, we have designed and synthesized several series of oxindoles to determine the structural requirements for AMPK inhibition and to improve selectivity. We identified two potent, novel oxindole-based AMPK inhibitors that were designed to interact with the DFG motif in the ATP-binding site of AMPK, this key feature evades interaction with the common recptor tyrosine kinase targets of sunitinib. Cellular engagement of AMPK by these oxindoles was confirmed by the inhibition of phosphorylation of acetyl-CoA carboxylase (ACC), a known substrate of AMPK, in myeloid leukemia cells. Interestingly, although AMPK is highly expressed and activated in K562&nbsp;cells these oxindole-based AMPK inhibitors did not impact cell viability or result in significant cytotoxicity. Our studies serve as a platform for the further development of oxindole-based AMPK inhibitors with therapeutic potential. Spatial distribution characteristics of heavy metal (Cd, Pb, Cr, Cu, Zn, and Hg) contents and their ecological risks in the farmland along the shoreline of the Caohai wetland were investigated. Incubation experiments were also conducted to characterize the emission of heavy metals across soil-water interface if the farmland was reclaimed to wetland. The results showed that spatial distribution characteristics of these heavy metal contents were significantly different. Concentrations of Cd, Zn, and Hg were higher than the corresponding geochemical background levels. Ecological risk assessment suggested that the farmland along the shoreline of Caohai wetland were characterized by non-pollution or slight pollution of Pb, Cr, and Cu, moderate pollution of Cd, slight to moderate pollution of Hg, and slight pollution of Zn. Emission rates of Cd, Zn, and Hg across soil/sediment-water interface first increased, then decreased and finally reached equilibrium after the farmland soil was submersed. The contribution-rates of Cd, Zn, and Hg transferring from sediment to overlying water were calculated to be 12.7%, 14.8%, and 10.4%, respectively. We conclude that environmental issues caused by heavy metals, especially by Cd, Zn, and Hg, in the farmland along the shoreline of the Caohai wetland should be paid great attention. Environmentally toxic organic pollutants, namely methylene blue (MB), neutral red (NR), Rhodamine B (RhB), and methyl orange (MO) dyes contain highly toxic, carcinogenic, non-biodegradable, and colored pigments which cause harm for humans and aquatic organisms even at low concentrations. To detoxify these toxic organic pollutants from the wastewater, the bimetallic solid solution-typed In-Mo(O,S)2 catalyst with various indium (In) contents were synthesized at low temperature through a simple precipitation method. https://www.selleckchem.com/products/vcmmae.html The morphological, structural, chemical compositions, electrochemical and optical properties of the catalysts were thoroughly characterized. The photodegradation performance of the In-Mo(O,S)2 catalysts over the cationic, anionic and neutral dyes were studied under visible light irradiation. It has been observed that the photocatalytic activity was enhanced as In was added to the Mo(O,S)2 catalyst, and In-Mo(O,S)2-20 was found to be the best composition to completely degrade four organic dyes. The dye degradation had rate constant values of 9.5&nbsp;×&nbsp;10-2 min-1, 6.3&nbsp;×&nbsp;10-2 min-1, 4.4&nbsp;×&nbsp;10-2 min-1, and 15.7&nbsp;×&nbsp;10-1 min-1 for MB (20&nbsp;ppm), NR (20&nbsp;ppm), RhB (10&nbsp;ppm), and MO (10&nbsp;ppm) dyes, respectively. The active species for degradation of MB is different from those for RhB and MO. Single phase In-Mo(O,S)2-20 capable to degrade four kinds of dyes at a fast rate is a good photocatalyst. Bisphenol A (BPA) is a synthetic xenoestrogen diffused worldwide. Humans are chronically exposed to low doses of BPA from food and drinks, thus BPA accumulates in tissues posing human health risk. In this study, we investigated the effects of BPA on peripheral blood mononuclear cells (PBMC) from human healthy donors, and in glia and microglia of rat offspring at postnatal day 17 (17PND) from pregnant females who received BPA soon after coupling and during lactation and weaning. Results indicated that BPA affected Phytoemagglutinin (PHA) stimulated PBMC proliferation causing an S-phase cell cycle accumulation at nanomolar concentrations while BPA was almost ineffective in resting PBMC. Furthermore, BPA induced chromosome aberrations and the appearance of shattered cells characterized by high number of fragmented and pulverized chromosomes, suggesting that the compound could cause a massive genomic rearrangement by inducing catastrophic events. The BPA-induced DNA damage was observed mainly in TCD4+ and TCD8+ subsets of T lymphocytes and was mediated by the increase of ERK1/2 phosphorylation, p21/Waf1 and PARP1 protein expression. Intriguingly, we observed for the first time that BPA-induced effects were associated to a sex specific modulation of ERα and ERβ in human PBMC. Immunofluorescence analysis of rat hippocampus corroborated in&nbsp;vitro findings showing that BPA induced ?H2AX phosphorylation in microglia and astrocytosis by decreasing ERα expression within the dentate gyrus. Overall these results suggest that BPA can alter immune surveillance functions at both peripheral and central level with a potential risk for cancer, neuroinflammation and neurodegeneration. Atmosphere, water, and soil contamination with toxic compounds is a recurrent issue due to environmental disasters, coal burning, urbanization, and industrialization, allf of which have contributed to soil contamination over the decades. Consequently, understanding of the nanomineralogy and potential hazardous elements (PHEs) in coal area soil are always a vital topic since contaminated soil can affect the environment, agricultural safety, and human health. Colombian coal mining in the La Guajira zone has been usually been related with important health and ecological effects. Coalmine rejects from active and/or abandoned operations are causes of high intensities of potential hazardous elements (PHEs) and nanoparticles (NPs, minerals and/or amorphous compounds). Although these pollutants can be reduced by sorption to NPs, in this study was recognized an analytical procedure for understand distribution of PHEs and their relationship to iron NPs(Fe-NPs) was recognized. Non and poorrly crystalline Fe-NPs performances as the major PHEs association.